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Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin

Monica Força Lima, Ricardo Jorgensen Cassella, Wagner Felippe Pacheco

Abstract


This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). The proposed spectrophotometric procedures were validated with respect to linearity, ranges, precision, accuracy, detection and quantification limits. Calibration curves of the formed color products showed good linear relationships over the concentration range of 6-15 mg L-1. The proposed method has been successfully applied, which can be confirmed by interference test (comparison between the standard curves and addition of analyte), method precision (RSD 2.3% to 6 mg L-1), and by accuracy (statistically equivalent results between the proposed method and a chromatographic method of reference).

Keywords


Rosuvastatin/spectrophotometric determination; Rosuvastatin/charge transfer complex; Quinalizarin/charge transfer complex; Pharmaceutical formulations.

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DOI: http://dx.doi.org/10.1590/s2175-97902017000300075

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