Association of synaptosomal-associated protein 25 (SNAP-25) gene polymorphism with temperament and character traits in women with fibromyalgia syndrome

Authors

  • Atalay Dogru Dr. Ersin Arslan Training and Research Hospital, Department of Internal Medicine, Division of Rheumatology
  • Ayse Balkarli Antalya Training and Research Hospital, Department of Internal Medicine, Division of Rheumatology
  • Emre Tepeli Pamukkale University, Department of Medical Biology
  • Emel Aydin Pamukkale University, Department of Psychiatry
  • Veli Cobankara Pamukkale University, Department of Internal Medicine, Division of Rheumatology

DOI:

https://doi.org/10.1590/acp.v45i4.152993

Keywords:

Fibromyalgia syndrome, SNAP-25 gene polymorphism, temperament and character inventory

Abstract

Background: Synaptosomal-associated protein 25 (SNAP-25) may be contribute to the pathogenesis of fibromyalgia Syndrome (FMS) by affecting the release of neurotransmitters. Objectives: We aimed to investigate the relationship between the SNAP-25 gen (DdeI = rs1051312 and MnlI = rs3746544) polymorphism and the temperament and character traits. Methods: A total of 85 female patients diagnosed with FMS and 70 age-matched healthy female subjects were enrolled into the study. The Temperament and Character Inventory (TCI) were performed on all the patients. SNAP-25 gene polymorphism was determined in the patients group and controls group. Results: No significant difference between groups was found regarding the distribution of SNAP-25 MnlI polymorphism (p > 0.05), but it was seen that the frequency of TC genotype for DdeI gene was higher in the patients group (p < 0.05). Increased hazard avoidance was found in the patients group (p < 0.05). When TCI scores were assessed in terms of SNAP-25 gene polymorphism, no statistically significant relationship was detected between the TT, TG, GG genotypes for MnlI gen and TCI scores (p > 0.05). However, increased hazard avoidance was detected in patients with TC genotype for DdeI gene compared to patients without such genotype. Discussion: SNAP-25 might be an etiological factor in FMS pathogenesis and might affect personality traits of FMS patients by mediating neurotransmitter release.

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Published

2018-12-19

Issue

Vol. 45 No. 4 (2018)

Section

Original Articles

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Association of synaptosomal-associated protein 25 (SNAP-25) gene polymorphism with temperament and character traits in women with fibromyalgia syndrome. (2018). Archives of Clinical Psychiatry (São Paulo), 45(4), 88-93. https://doi.org/10.1590/acp.v45i4.152993