PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population

Authors

  • Ayse Feyda Nursal Hitit University, Faculty of Medicine, Department of Medical Genetics
  • Pinar Cetinay Aydı Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Department of Psychiatry
  • Mehmet Atilla Uysal University of Health Sciences, Yedikule Hospital for Chest Diseases and Thoracic Surgery Training and Research Hospital
  • Mustafa Pehliva Gaziantep University, Faculty of Medicine, Department of Haematology
  • Yasemin Oyaci Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology
  • Sacide Pehliva Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology

DOI:

https://doi.org/10.1590/0101-60830000000235

Keywords:

Substance use disorder, smoking status, Per3, VNTR, PCR

Abstract

Background: Substance use and smoking exert devastating impact on sleep, especially hindering the ease of falling asleep, compromising the sleep maintenance, and distorting the sleep cycles. PERIOD genes are believed to play a role in individual differences in sleep timing by influencing circadian. Objective: The aim of this study was to ascertain whether Per3 VNTR variant affects suspectibility of individuals to substance use disorder (SUD) and smoking status in a Turkish population. Methods: A total of 549 subjects, including 212 SUD patients, 160 smoker, and 177 healthy controls, matched by ethnicity, age, and gender, were recruited in a case-control study. Genotyping of Per3 variant was performed using PCR method. Results: When the SUD, smoker groups and controls were compared in terms of 5R/5R, 5R/4R, 4R/4R genotypes, no significant difference was observed. Besides, allele frequencies of Per3 VNTR were similar among the groups. Discussion: Our data indicate that Per3 VNTR variant is not associated with the risk of SUD and smoking status in our population.

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Published

2019-06-12

Issue

Vol. 47 No. 3 (2020)

Section

Original Articles

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population. (2019). Archives of Clinical Psychiatry (São Paulo), 47(3), 71-74. https://doi.org/10.1590/0101-60830000000235