Synchronous eyelid oncocytoma and conjunctival intraepithelial neoplasia

Authors

DOI:

https://doi.org/10.4322/acr.2020.235

Keywords:

Eyelid Neoplasms, Papilloma, Pterygium

Abstract

Oncocytoma of the eyelid is a rare neoplasm. Oncocytoma associated with an ocular surface squamous neoplasm, namely conjunctival intraepithelial neoplasia, is very hard to find in the literature. Herein we report a case of a 53-year-old male who presented with a swelling in the right lower lid over the last 6 years, along with a growth in the conjunctiva of the same eye for the last 2 years and encroaching upon the cornea for the last 4 months. Excision biopsy of the lower lid mass showed histopathological features consistent with oncocytoma. The conjunctival tissue revealed conjunctival intraepithelial neoplasia 3 (severe dysplasia). This case documents a rare synchronous dual ocular neoplasia, a very unlikely coexistence of oncocytoma with conjunctival intraepithelial neoplasia.

Downloads

Download data is not yet available.

References

Biggs SL, Font RL. Oncocytic lesions of the caruncle and other ocular adnexa. Arch Ophthalmol. 1977;95(3):474-8. http://dx.doi.org/10.1001/archopht.1977.04450030116017. PMid:843279.

Østergaard J, Prause JU, Heegaard S. Oncocytic lesions of the ophthalmic region: a clinicopathological study with emphasis on cytokeratin expression. Acta Ophthalmol. 2011;89(3):263-7. http://dx.doi.org/10.1111/j.1755-3768.2009.01677.x. PMid:19843013.

Riedel K, Stefani FH, Kampik A. Oncocytoma of the ocular adnexa. Klin Monatsbl Augenheilkd. 1983;182(6):544-8. http://dx.doi.org/10.1055/s-2008-1054850. PMid:6876649.

Thaller VT, Collin JR, McCartney AC. Oncocytoma of the eyelid: a case report. Br J Ophthalmol. 1987;71(10):753-6. http://dx.doi.org/10.1136/bjo.71.10.753. PMid:3676144.

Østergaard J, Prause JU, Heegaard S. Caruncular lesions in Denmark 1978-2002: a histopathological study with correlation to clinical referral diagnosis. Acta Ophthalmol Scand. 2006;84(1):130-6. http://dx.doi.org/10.1111/j.1600-0420.2005.00543.x. PMid:16445453.

Fenelon EM, Balby IT, Neves NTD, Figueiredo F, Duarte ECB, Tzelikis PF. Oncocytoma of the lacrimal gland: a case report. Arq Bras Oftalmol. 2017;80(2):128-30. http://dx.doi.org/10.5935/0004-2749.20170031. PMid:28591289.

Cameron JR, Barras CW. Oncocytoma of the eyelid. Acta Ophthalmol Scand. 2005;83(1):125. http://dx.doi.org/10.1111/j.1600-0420.2005.00346.x. PMid:15715577.

Al-Mohtaseb Z, Lee S, Yen MT. Oncocytoma of the upper conjunctival fornix. Eye Rep. 2011;1(7):17-9.

Rodgers IR, Jakobiec FA, Krebs W, Hornblass A, Gingold MP. Papillary oncocytoma of the eyelid. A previously undescribed tumor of apocrine gland origin. Ophthalmology. 1988;95(8):1071-6. http://dx.doi.org/10.1016/S0161-6420(88)33068-X. PMid:2852788.

Fukuo Y, Hirata H, Takeda N, Hayami H, Katayama T. A case of oncocytoma in the eyelid. Ophthalmologica. 1994;208(1):54-7. http://dx.doi.org/10.1159/000310452. PMid:8145989.

Mittal R, Rath S, Vemuganti GK. Ocular surface squamous neoplasia – Review of etiopathogenesis and an update on clinic-pathological diagnosis. Saudi J Ophthalmol. 2013;27(3):177-86. http://dx.doi.org/10.1016/j.sjopt.2013.07.002. PMid:24227983.

Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET. Human papillomavirus infection and ocular surface disease. Int J Oncol. 2019;54(5):1503-10. http://dx.doi.org/10.3892/ijo.2019.4755. PMid:30896784.

Ateenyi-Agaba C. Conjunctival squamous-cell carcinoma associated with HIV infection in Kampala, Uganda. Lancet. 1995;345(8951):695-6. http://dx.doi.org/10.1016/S0140-6736(95)90870-6. PMid:7885126.

Newton R, Ferlay J, Reeves G, Beral V, Parkin DM. Effect of ambient solar ultraviolet radiation on incidence of squamous-cell carcinoma of the eye. Lancet. 1996;347(9013):1450-1. http://dx.doi.org/10.1016/S0140-6736(96)91685-2. PMid:8676629.

Reidy JJ, Bouchard CS, Florakis GJ, et al. Basic and clinical science course. San Francisco: American Academy of Ophthalmology. p. 226-33.

Oellers P, Karp CL, Sheth A, et al. Prevalence, treatment, and outcomes of coexistent ocular surface squamous neoplasia and pterygium. Ophthalmology. 2013;120(3):445-50. http://dx.doi.org/10.1016/j.ophtha.2012.08.010. PMid:23107578.

Say EA, Shields CL, Bianciotto C, Eagle RC Jr, Shields J. Oncocytic lesions (oncocytoma) of the ocular adnexa: report of 15 cases and review of literature. Ophthal Plast Reconstr Surg. 2012;28(1):14-21. http://dx.doi.org/10.1097/IOP.0b013e31822dd236. PMid:21956543.

Shields JA, Eagle RC, Marr BP, Shields CL, Grossniklaus HE, Stulting RD. Invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. Cornea. 2007;26(8):1014-6. http://dx.doi.org/10.1097/ICO.0b013e3180cfe80e. PMid:17721310.

Roy A, Rath S, Das S, Vemuganti GK, Parulkar G. Penetrating sclerokeratoplasty in massive recurrent invasive squamous cell carcinoma. Ophthal Plast Reconstr Surg. 2011;27(2):e39-40. http://dx.doi.org/10.1097/IOP.0b013e3181eea1d4. PMid:20871462.

Shields CL, Demirci H, Marr BP, Masheyekhi A, Materin M, Shields JA. Chemoreduction with topical mitomycin C prior to resection of extensive squamous cell carcinoma of the conjunctiva. Arch Ophthalmol. 2005;123(1):109-13. http://dx.doi.org/10.1001/archopht.123.1.109. PMid:15642823.

Hӧllhumer R, Williams S, Michelow P. Observational study of ocular surface squamous neoplasia: risk factors, diagnosis, management and outcomes at a tertiary eye hospital in South Africa. PLoS One. 2020;15(8):e0237453. http://dx.doi.org/10.1371/journal.pone.0237453. PMid:32780766.

Cicinelli MV, Marchese A, Bandello F, Modorati G. Clinical management of ocular surface squamous neoplasia: a review of the current evidence. Ophthalmol Ther. 2018;7(2):247-62. http://dx.doi.org/10.1007/s40123-018-0140-z. PMid:30030703.

Shields CL, Chien JL, Surakiatchanukul T, Sioufi K, Lally SE, Shields JA. Conjunctival tumors: review of clinical features, risks, biomarkers, and outcomes- the 2017 J. Donald M. Gass lecture. Asia Pac J Ophthalmol. 2017;6(2):109-20. PMid:28399347.

Maskin SL. Regression of limbal epithelial dysplasia with topical interferon. Arch Ophthalmol. 1994;112(9):1145-6. http://dx.doi.org/10.1001/archopht.1994.01090210029007. PMid:8085957.

Karp CL, Moore JK, Rosa RH Jr. Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon α-2b. Ophthalmology. 2001;108(6):1093-8. http://dx.doi.org/10.1016/S0161-6420(01)00577-2. PMid:11382635.

Downloads

Published

2021-02-25

Issue

Section

Clinical Case Report

How to Cite

Chowdhury, Z. ., Nongrum, B. ., & Rajbongshi, C. . (2021). Synchronous eyelid oncocytoma and conjunctival intraepithelial neoplasia. Autopsy and Case Reports, 11, e2020235. https://doi.org/10.4322/acr.2020.235