Pulmonary histopathology in fatal paraquat poisoning

Senthil  Kumar; Shikha  Gupta; Yogender Singh  Bansal; Amanjit  Bal; Pulkit  Rastogi; Valliappan  Muthu; Vanshika  Arora

doi:10.4322/acr.2021.342

Authors

Senthil Kumar Postgraduate Institute of Medical Education and Research, Department of Forensic Medicine, Chandigarh, India https://orcid.org/0000-0001-5622-2137
Shikha Gupta Postgraduate Institute of Medical Education and Research, Department of Forensic Medicine, Chandigarh, India https://orcid.org/0000-0001-8905-3296
Yogender Singh Bansal Postgraduate Institute of Medical Education and Research, Department of Forensic Medicine, Chandigarh, India https://orcid.org/0000-0002-5752-7968
Amanjit Bal Postgraduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India https://orcid.org/0000-0002-1457-8589
Pulkit Rastogi Postgraduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India https://orcid.org/0000-0002-9634-737X
Valliappan Muthu Postgraduate Institute of Medical Education and Research, Department of Pulmonary Medicine, Chandigarh, India https://orcid.org/0000-0003-0410-8468
Vanshika Arora Postgraduate Institute of Medical Education and Research, Department of Forensic Medicine, Chandigarh, India https://orcid.org/0000-0002-9686-369X

DOI:

https://doi.org/10.4322/acr.2021.342

Keywords:

Paraquat, Acute toxicity, Autopsy, Histology, Lung injury

Abstract

Paraquat is a potent herbicide widely used in the Indian agriculture industry. Human fatality due to paraquat poisoning is not uncommon in this country. The primary effect of paraquat is on the lungs, and the resultant pulmonary damage leads to the patient’s demise. There is a high mortality rate in paraquat poisoning as the treatment is usually supportive with no known antidote. There are limited human studies that have observed the histopathological changes in lungs in paraquat poisoning. The authors have discussed the time-related histopathological changes in lungs in paraquat poisoning on autopsy subjects. The role of anticoagulants and fibrinolytic agents in the treatment of this poisoning has also been discussed.

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References

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Pulmonary histopathology in fatal paraquat poisoning

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