Secondary primary tumor mimicking osteoradionecrosis
DOI:
https://doi.org/10.4322/acr.2021.389Keywords:
Nasopharyngeal carcinoma, second primary neoplasms, squamous cell carcinoma of head and neck, osteoradionecrosis, case reportsAbstract
Nasopharyngeal carcinoma (NPC) is a malignant tumor rarely found in the head and neck, representing about 1% of all malignancies. The main treatment for NPC is radiation therapy, which is often given in combination with chemotherapy. However, such treatment may lead to long‐term complications, including second primary tumors (SPTs) and osteoradionecrosis (ORN). Both complications have similar radiological characteristics, which can lead to erroneous diagnoses. This paper describes a case of a second primary tumor in a patient after 20 years of radiotherapy in the area where a previous extraction was performed, mimicking an osteoradionecrosis process.
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Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet. 2019;394(10192):64-80. http://dx.doi.org/10.1016/S0140-6736(19)30956-0. PMid:31178151.
Xi M, Liu MZ, Wang HX, et al. Radiation-induced sarcoma in patients with nasopharyngeal carcinoma: a single-institution study. Cancer. 2010;116(23):5479-86. http://dx.doi.org/10.1002/cncr.25329. PMid:20715161.
Liu C, Liao L, Wu G, et al. Radiation-induced second primary squamous cell carcinoma of the oral cavity after radiotherapy for nasopharyngeal carcinoma. Oral Oncol. 2020;109:104863. http://dx.doi.org/10.1016/j.oraloncology.2020.104863. PMid:32604060.
Yang Q, Mo Y, Zhao Q, et al. Radiation-induced sarcomas of the head and neck in post-radiation nasopharyngeal carcinoma. Radiol Med (Torino). 2017;122(1):53-60. http://dx.doi.org/10.1007/s11547-016-0695-5. PMid:27738788.
Lim SW, Mohamed T, Tengku I. Radiation-induced sarcoma post radiotherapy treatment of nasopharyngeal carcinoma. Int J Health Sci Res. 2021;11:111-3.
Kong L, Lu JJ, Hu C, Guo X, Wu Y, Zhang Y. The risk of second primary tumors in patients with nasopharyngeal carcinoma after definitive radiotherapy. Cancer. 2006;107(6):1287-93. http://dx.doi.org/10.1002/cncr.22119. PMid:16909425.
Thariat J, Italiano A, Collin F, et al. Not all sarcomas developed in irradiated tissue are necessarily radiation-induced – Spectrum of disease and treatment characteristics. Crit Rev Oncol Hematol. 2012;83(3):393-406. http://dx.doi.org/10.1016/j.critrevonc.2011.11.004. PMid:22138059.
Marx RE. Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg. 1983;41(5):283-8. http://dx.doi.org/10.1016/0278-2391(83)90294-X. PMid:6572704.
Dai L, Fang Q, Li P, Wu J, Zhang X. Secondary squamous cell carcinoma of the oral cavity after nasopharyngeal carcinoma. Cancer Res Treat. 2020;52(1):109-16. http://dx.doi.org/10.4143/crt.2019.202. PMid:31163959.
Strojan P, Corry J, Eisbruch A, et al. Recurrent and second primary squamous cell carcinoma of the head and neck: when and how to reirradiate. Head Neck. 2015;37(1):134-50. http://dx.doi.org/10.1002/hed.23542. PMid:24481720.
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