The many faces of endometriosis

Authors

DOI:

https://doi.org/10.4322/acr.2021.409

Keywords:

Endometriosis, Ovary, Pathology

Abstract

Endometriosis is a common disease; however, unusual findings may cause diagnostic difficulties. We present herein three cases illustrating different morphological appearances of endometriosis: 1) endometriosis with atypical hyperplasia associated with bilateral ovarian carcinoma (mixed clear cell/endometrioid in the left ovary and endometrioid in the right ovary); 2) deep infiltrating endometriosis with intravascular spread, polypoid configuration in peritoneal surfaces, and involvement of a lymph node; and 3) decidualized endometriosis with prominent myxoid/mucinous change and multivacuolated (pseudoxanthoma) cells. Awareness of uncommon morphological manifestations of endometriosis is important to avoid improper consideration of malignancy.

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References

McCluggage WG. Endometriosis-related pathology: a discussion of selected uncommon benign, premalignant and malignant lesions. Histopathology. 2020;76(1):76-92. http://dx.doi.org/10.1111/his.13970. PMid:31846535.

Irving JA, Clement PB. Diseases of the Peritoneum. In: Kumar RJ, Ellenson LH, Ronnett BM, editors. Blaustein’s pathology of the female genital tract. London: Springer; 2019. p. 771-840. http://dx.doi.org/10.1007/978-3-319-46334-6_13.

Krawczyk N, Banys-Paluchowski M, Schmidt D, Ulrich U, Fehm T. Endometriosis-associated malignancy. Geburtshilfe Frauenheilkd. 2016;76(2):176-81. http://dx.doi.org/10.1055/s-0035-1558239. PMid:26941451.

Fukunaga M, Nomura K, Ishikawa E, Ushigome S. Ovarian atypical endometriosis: its close association with malignant epithelial tumours. Histopathology. 1997;30(3):249-55. http://dx.doi.org/10.1046/j.1365-2559.1997.d01-592.x. PMid:9088954.

Tanase Y, Furukawa N, Kobayashi H, Matsumoto T. Malignant transformation from endometriosis to atypical endometriosis and finally to endometrioid adenocarcinoma within 10 years. Case Rep Oncol. 2013;6(3):480-4. http://dx.doi.org/10.1159/000355282. PMid:24163664.

Ooi K, Valentine R. Intravascular endometrial tissue in an ovary of a patient with abnormal endometrial histology. Pathology. 1994;26(2):212-4. http://dx.doi.org/10.1080/00313029400169501. PMid:8090596.

Scolyer RA, Carter J, Russell P. Aggressive endometriosis: report of a case. Int J Gynecol Cancer. 2000;10(3):257-62. http://dx.doi.org/10.1046/j.1525-1438.2000.010003257.x. PMid:11240684.

Dawson A, Fernandez ML, Anglesio M, Yong PJ, Carey MS. Endometriosis and endometriosis-associated cancers: new insights into the molecular mechanisms of ovarian cancer development. Ecancermedicalscience. 2018;12:803. http://dx.doi.org/10.3332/ecancer.2018.803. PMid:29456620.

Mostoufizadeh M, Scully RE. Malignant tumors arising in endometriosis. Clin Obstet Gynecol. 1980;23(3):951-63. http://dx.doi.org/10.1097/00003081-198023030-00024. PMid:7418292.

Abrao MS, Podgaec S, Dias JA Jr., et al. Deeply infiltrating endometriosis affecting the rectum and lymph nodes. Fertil Steril. 2006;86(3):543-7. http://dx.doi.org/10.1016/j.fertnstert.2006.02.102. PMid:16876165.

Nogales FF, Martin F, Linares J, Naranjo R, Concha A. Myxoid change in decidualized scar endometriosis mimicking malignancy. J Cutan Pathol. 1993;20(1):87-91. http://dx.doi.org/10.1111/j.1600-0560.1993.tb01257.x. PMid:8468423.

Hameed A, Jafri N, Copeland LJ, O’Toole RV. Endometriosis with myxoid change simulating mucinous adenocarcinoma and pseudomyxoma peritonei. Gynecol Oncol. 1996;62(2):317-9. http://dx.doi.org/10.1006/gyno.1996.0235. PMid:8751569.

Clement PB, Young RH, Scully RE. Necrotic pseudoxanthomatous nodules of ovary and peritoneum in endometriosis. Am J Surg Pathol. 1988;12(5):390-7. http://dx.doi.org/10.1097/00000478-198805000-00007. PMid:3364620.

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Published

2022-11-04

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Section

Clinical Case Report

How to Cite

Marcelo Luis Pereira de Souza Filho, Talita Porto da Costa, Nathanael Pinheiro de Freitas Junior, Maiara Ferreira de Souza, & Daniel Abensur Athanazio. (2022). The many faces of endometriosis. Autopsy and Case Reports, 12, e2021409. https://doi.org/10.4322/acr.2021.409