Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans

Autores

  • Letícia Fernandes da Rocha Universidade Federal do Rio Grande do Sul, Faculade de Farmácia
  • Bruna Pippi Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Microbiologia Agrícola e do Ambiente
  • Alexandre Meneghello Fuentefria Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Departamento de Análises
  • Adelina Mezzari Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Departamento de Análises https://orcid.org/0000-0003-4538-627X

DOI:

https://doi.org/10.1590/s2175-97902019000318599

Palavras-chave:

Cryptococcus neoformans, Ibuprofen, Itraconazole, Fluconazole, Synergism

Resumo

The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis.

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Publicado

2021-03-02

Edição

v. 56 (2020)

Seção

Article

Licença

Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

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Como Citar

Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans. (2021). Brazilian Journal of Pharmaceutical Sciences, 56, e18599 . https://doi.org/10.1590/s2175-97902019000318599