Evaluation of vitamin D and inflammatory markers in elderly
DOI:
https://doi.org/10.1590/s2175-97902022e20248Palavras-chave:
Inflammatory Markers, Vitamin D, ElderlyResumo
Vitamin D is an immune modulator, in addition to being interrelated with calcium homeostasis and bone metabolism. Recent studies have associated vitamin D with inflammatory processes. C-reactive protein (CRP), platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) have been used to determine inflammation. There is no consensus on the use of these markers to determine an association between inflammation and vitamin D levels. The objective of this study was to evaluate the association between inflammatory markers and vitamin D in the elderly. A cross-sectional, descriptive study was performed based on the analysis of vitamin D, CRP (quantitative determination of C-Reactive Protein by the ultra-sensitive method) and blood count of institutionalized elderly. In this study, 64% showed vitamin D deficiency, with mean value of 22 ng/mL. In the vitamin D deficient group, the mean values found were: CRP 4.5 mg/L; NLR 2.35 and PLR 119. In the group without vitamin D deficiency the mean values were: CRP 4 mg/L; NLR 1.87 and PLR 111 without statistical difference between the values of the analyzed parameters. The results point to a predominant profile of vitamin D deficiency in the evaluated individuals. No association was found between vitamin D values and the inflammatory markers analyzed.
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Akbas EM, Gungor A, Ozcicek A, Akbas N, Askin S, Polat M. Vitamin D and inflammation: evaluation with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Arch Med Sc. 2016;12(4):721-727.
Amer M, Qayyum R. Relation between serum 25-hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006). Am J Cardiol. 2012;109(2):226-230.
Atef SH. Vitamin D assays in clinical laboratory: Past, present and future challenges. J Steroid Biochem Mol Biol. 2018;175:136-137.
Augusto C, Paiva C, Bettinelli LA. Prevalência de hipovitaminose de sua severidade em idosos institucionalizados no município de Passo Fundo. Rev Contexto Saúde. 2013;11(20):1243-1250.
Azizieh F, Alyahya KO, Raghupathy R. Association between levels of vitamin D and inflammatory markers in healthy women. J Inflamm Res. 2016;9:51-57.
Barral D. Vitamina D: Uma Abordagem Molecular. Pesq Bras Odontop Clín Integr. 2007;7(3):309-315.
Chang SW, Lee HC. Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019;60(3):237-244.
Collares GB, Paulino UHM. Aplicações Clínicas atuais da proteína C reativa. Rev Med Minas Gerais. 2006;16(4):227-233.
Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, et al. Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014;25(10):2359-2381.
Cruvinel WM, Júnior DM, Araújo JAP, Catelan TTT, de Souza AWS, da Silva NP, et al. Immune system - part I fundamentals of innate immunity with emphasis on molecular and cellular mechanisms of inflammatory response. Rev Bras Reumatol. 2010;50(4):443-461.
De Oliveira V, Muller LG, Dutra LE, Boff BD, Stauder GZ. Influencia de la vitamina D en la salud humana. Acta Bioq Clin Latinoam. 2014;48(3):329-337.
Du Clos TW. Function of C-reactive protein. Ann Med. 2000 32(4):274-278.
Ferreira CES, Maeda SS, Batista MC, Lazaretti-Castro M, Vasconcellos LS, Madeira M et al. Consensus - reference ranges of vitamin D [25(OH)D] from the Brazilian medical societies. Brazilian Society of Clinical Pathology/ Laboratory Medicine (SBPC/ML) and Brazilian Society of Endocrinology and Metabolism (SBEM). J Bras Patol Med Lab. 2017;53(6):377-381.
Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. The Platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med. 2019;39(4):345-357.
Heijboer AC, Blankenstein MA, Kema IP, Buijs MM. Accuracy of 6 routine 25-hydroxyvitamin D assays: influence of vitamin D binding protein concentration. Clin Chem. 2012;58(3):543-548.
Herbeth B, Siest G, Henny J. High sensitivity C-reactive protein (CRP) reference intervals in the elderly. Clin Chem Lab Med. 2001;39(11):1169-1170.
Holick MF. Sunlight Dilemma: risk of skin cancer or bone disease and muscle weakness. Lancet. 2001;357(9249):4-6.
Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009;19(2):73-78.
Koseoglu SB. Bone loss & platelet-to-lymphocyte ratio. Biomark Med. 2017;11(1):5-10.
Kushner I. C-reactive protein and the acute-phase response. Hospital Practice (Office Ed.). 1990;25(3A):13,16,21-28.
Li J, Chen Q, Luo X, Hong J, Pan K, Lin X, et al. Neutrophil-to-Lymphocyte ratio positively correlates to age in healthy population. J Clin Lab Anal. 2015;29(6):437-443.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010;170(13):1135-1141.
Marques CDL, Dantas AT, Fragoso TS, Duarte ALBP. The importance of vitamin D levels in autoimmune diseases. Rev Bras Reumatol . 2010;50(1):67-80.
Mendes BB, Oliveira ACR, Alcântara KC. Comparison of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in normoglycemic and hyperglycemic subjects. Einstein (Sao Paulo, Brazil). 2019;17(1):eAO4403.
Monteiro Júnior FC, Mandarino NR, Salgado JVL, Lages JS, Salgado Filho N. Vitamin D deficiency: a new cardiovascular risk factor?. Int J Cardiovasc Sci. 2014;27(5):356-365.
Oliveira C, Biddulph JP, Hirani V, Schneider IJC. Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA). J Nutr Sci. 2017;6:e1. DOI:10.1017/jns.2016.37.
» https://doi.org/10.1017/jns.2016.37
Saraiva GL, Cendoroglo MS, Ramos LR, Araújo LMQ, Vieira JGH, Maeda SS et al. Prevalência da deficiência, insuficiência de vitamina D e hiperparatiroidismo secundário em idosos institucionalizados e moradores na comunidade da Cidade de São Paulo, Brasil. Arq Bras Endocrinol Metab. 2007;51(3):437-442.
Scalco R, Furlanetto TW. Prevalência de hipovitaminose D em idosos residentes em clínicas geriátricas beneficentes de Porto Alegre. [dissertação]. 2008. In Universidade Federal do Rio Grande do Sul.
Sousa SES, Sales MC, Araújo JRT, Sena-Evangelista KCM, Lima KC, Pedrosa LFC. High Prevalence of Hypovitaminosis D in Institutionalized Elderly Individuals is Associated with Summer in a Region with High Ultraviolet Radiation Levels. Nutrients. 2019;11(7):1516.
Tang Y, Fung E, Xu A, Lan HY. C-reactive protein and ageing. Clin Exp Pharmacol Physiol. 2017;44 Suppl 1:9-14.
Terushkin V, Bender A, Psaty EL, Engelsen O, Wang SQ, Halpern AC. Estimated equivalency of vitamin D production from natural sun exposure versus oral vitamin D supplementation across seasons at two US latitudes. J Am Acad Dermatol. 2010;62(6):929.e1-9.
Timms PM, Mannan N, Hitman GA, Noonan K, Mills PG, Syndercombe-Court D et al. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? QJM. 2002;95(12):787-796.
Tolan NV, Yoon EJ, Brady AR, Horowitz GL. Price of High-Throughput 25-Hydroxyvitamin D Immunoassays: Frequency of Inaccurate Results. J Appl Lab Med. 2018;2(6):868-879.
Yildirim I, Hur E, Kokturk F. Inflammatory markers: C-reactive protein, erythrocyte sedimentation rate, and leukocyte count in vitamin D deficient patients with and without chronic kidney disease. Int J Endocrinol. 2013;2013:802165.
Zhang J, Zhang HY, Li J, Shao XY, Zhang CX. The elevated NLR, PLR and PLT may predict the prognosis of patients with colorectal cancer: a systematic review and meta-analysis. Oncotarget. 2017;8(40):68837-68846.
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