Association between disease activity and quality of life among patients with rheumatoid arthritis

Autores

  • Romulo Lopes da Costa Medicine Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil
  • Felício de Freitas Neto Medicine Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil
  • Diogo von Gaevernitz Lima Medicine Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil
  • Fabiana Postiglione Mansani Medicine Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil
  • Marcelo Derbli Schafranski Medicine Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil
  • Bruno Queiroz Zardo Medicine Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil
  • Alceu de Oliveira Toledo Júnior Clinical and Toxicological Analysis Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil
  • Lorena de Freitas Calixto Medicine Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil
  • José Carlos Rebuglio Vellosa Clinical and Toxicological Analysis Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil
  • Elisangela Gueiber Montes Clinical and Toxicological Analysis Department, State University of Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil https://orcid.org/0000-0003-1694-085X

DOI:

https://doi.org/10.1590/s2175-97902022e20626

Palavras-chave:

Arthritis, Disease activity, Quality of life

Resumo

The aim of this study is the association between the scores of disease activity, functional capacity and quality of life among patients diagnosed with rheumatoid arthritis, under clinical treatment at the Regional University Hospital of Campos Gerais - Wallace Thadeu de Mello and Silva. The sample was composed by volunteer patients, who freely underwent 3 research questionnaires. With the results of the survey, the disease activity score was correlated to the functional capacity and the quality-of-life scores. A mean of 3.87 and 1.2 was observed for the disease activity and the functional capacity scores, respectively, yet not achieving a correlation between those two variables. A strong correlation between the disease activity and the “functional capacity”, “general health status” and “mental health” domains was found. The lowest average observed corresponded to “physical limitation”, from the quality-of-life questionnaire. There was no statistically significant correlation between disease activity and functional capacity, although disease activity seems to affect the mental health, general health status and functional capacity of patients.

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Referências

Combe B, Cantagrel A, Goupille P, Bozonnat MC, Sibilia J, Eliaou JF, et al. Predictive factors of 5-year health assessment questionnaire disability in early rheumatoid arthritis. J Rheumatol. 2003;30(11):2344-9.

Courvoisier N, Dougados H, Cantagrel Um, Goupille P, Meyer O, Sibilia J, et al. Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study. Arthritis Res Ther. 2008;10(5):R106. doi: 10.1186/ar2498.

» https://doi.org/10.1186/ar2498.

Drossaers-Bakker KW, de Buck M, van Zeben D, Zwinderman AH, Breedveld FC, Hazes JM. Long-term course and outcome of functional capacity in rheumatoid arthritis: the effect of disease activity and radiologic damage over time. Arthritis Rheum. 1999;42(9):1854-60.

Gaujoux-Viala C, Mouterde L, Baillet Um, Claudepierre P, Fautrel B, Le Loet X, et al. Evaluating disease activity in rheumatoid arthritis: which composite index is best? A systematic literature analysis of studies comparing the psychometric properties of the DAS, DAS28, SDAI and CDAI. Joint Bone Spine. 2012;79(2):149-55.

Linde L, Sörensen J, Ostergaard M, Hörsley-Petersen K, Hetland ML. Health-Related Quality of Life: Validity, Reliability, and Responsiveness of SF-36, EQ-15D, EQ-5D, RAQoL, and HAQ in Patients with Rheumatoid Arthritis. J Rheumatol. 2008;35(8):1528-37.

Mota LMH, Laurindo IM, Santos NL. Avaliação prospectiva da qualidade de vida em uma coorte de pacientes com artrite reumatoide inicial. Rev Bras Reumatol. 2010;50(3):249-261.

Ollier WER, Harrison B, Symmons D. What is the natural history of rheumatoid arthritis? Best Pract Res Clin Rheumatol. 2001;15(1):27-48.

Prevoo ML, van Hof Hof, Kuper HH, Leeuwen MA, Puttle LB, Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum . 1995;38(1):44-8.

van der Heijde DM, Van’t Hof MA, van Riel PL, Theunisse LA, Lübbert EW, van Leeuwen MA, et al. Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score. Ann Rheum Dis. 1990;49(11):916-20.

van Vollenhoven RF. New and future agents in the treatment of rheumatoid arthritis. Discov Med. 2010; 9(47):319-27.

Walker JG, Littlejohn GO. Measuring quality of life in rheumatic conditions. Clin Rheumatol. 2007;26(5):671-3.

Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J, et al. Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis . 2009;68(6):954-60.

Young A, Dixey J, Cox N, Davies P, Emery P, Gallivan S. How does functional disability in early rheumatoid arthritis (RA) affect patients and their lives? Results of 5 years of follow-up in 732 patients from the Early RA Study (ERAS). Rheumatology (Oxford). 2000;39(6):603-11.

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Publicado

2023-02-10

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Original Article

Como Citar

Association between disease activity and quality of life among patients with rheumatoid arthritis. (2023). Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e20626

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