Inhibition of calculi forming oxalate by dietary Basella rubra organs

Litholytic activity

Autores

  • Ramu Govindan Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamilnadu, India https://orcid.org/0000-0002-0572-9517
  • Roan Ngoc Anh Huy Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamilnadu, India
  • Navanita Sivaramakumar Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamilnadu, India
  • Rajesh Raman Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, India
  • Saravanan Jayaraman Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, India
  • Duraiswamy Basavan Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamilnadu, India
  • Dhanabal S Palanisamy Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Re

DOI:

https://doi.org/10.1590/s2175-97902022e20582

Palavras-chave:

Calculi, Litholytic, Basella rubra , Plant organs

Resumo

The inhibition of calculi forming oxalate by dietary Basella rubra plant organs leaf and stem pod has been investigated. The weight reduction assay was studied. Also a concoction of the plant organs was tested. Leaf extract was found with considerable activity whereas the concoction seems to be not much active as the stem pod extract. Soluble oxalate of the plant organs are partially removed prior to extraction of active constituents. The active component/s seem to be a non-protein and non-tannin molecule/s that may act through inhibition of calcium accumulation there by proving the positive activity against the calculi or kidney stone. Regular consumption of leaf and stem pod extracts of our plant would be helpful in calculi prophylaxis.

Downloads

Os dados de download ainda não estão disponíveis.

Referências

Adegoke AA, Iberi PA, Akinpelu D, Aiyegoro OA, Mboto C. Studies on phytochemical screening and antimicrobial potentials of Phyllanthus amarus against multiple antibiotic resistant bacteria. Int J Appl Res Nat Prod. 2010;3(3):6-12.

Aggarwal A,Singla S, Gandhi M, Tandon C. Preventive and curative effects of Achyranthes aspera L. extract in experimentally induced nephrolithiasis. Indian J Exp Biol.2012;50(3):201-208.

Alelign T, Petros B. Kidney Stone Disease: An Update on Current Concepts. Hind Adv Urol. 2018;12:122-127.

Alkhunaizi MA. Urinary stones in Eastern Saudi Arabia. Urol Ann. 2016;8(1):6-9.

Benramdane L, Bouatia M, Idrissi MOB, Draoui M. Infrared analysis of urinarystones, using a single reflection accessory and KBr pallet transmission. Spectrosc Lett.2008;41(2):72-80.

Boham BA, Koupai-Abyazani MR. Flavonoids and condensed tannins from leaves of Hawairan Vaccinium valiculatum and Vaccinium calycinium. Pacific Sci. 1994;48(4):458-463.

Boxi M, Rajesh Y, Kumar VR, Praveen B, Mangamma K. Extraction, phytochemical screening and in vitro evaluation of anti-oxidant properties of Commicarpus chinesis (aqueous leaf extract). Int J Pharm Biosci. 2010;1(4):537-547.

Caliskan M. The metabolism of oxalic acid. Turk J Zool. 2000;24(1):103-106.

da Costa LM, Tronto J, Constantino VRL, Fonseca MKA, Oliveira AP, da Costa MR. Extraction and concentration of biogenic calcium oxalate from plant leaves. Rev Bras Ciênc Solo. 2009;33(3):729-733.

Ferraro MP, Taddei L, Croppi E, Gambaro G. GEA Firenze study group. Prevalence of renal stones in an Italian urban population: a general practice-based study. Urol Res. 2012;40(2):517-522.

Fouada A, Yamina S, Nait MA, Mohammed B, Abdlekrim R. In vitro and in vivo antilithiatic effect of saponin rich fraction isolated from Herniaria hirsuta J Bras Nefrol. 2006;28(4):199-203.

Franceschi VR, Nakata PA. Calcium oxalate in plants: Formation and function. Ann Rev Plant Biol. 2005;56:41-71.

Gaur RD, Sharma J, Painuli RM. Plants used in traditional healthcare of livestock by Gujjar community of sub-himalayan tracts, Uttarakhand, India. Ind J Nat Prod Res. 2010;1(2):243-248.

George PM. Encyclopedia of Foods. Humane Press; Washington. 2003;1:526.

Haneefa KPM, Abraham A, Saraswathi R, Mohanta G, Nayar C. Formulation and evaluation of herbal gel of Basella alba for wound healing activity. J Pharma Sci Res. 2012;4(1):1642-1648.

Jha R, Ramani PT, Dhara P, Desai S, Meshram DB. Phytochemical analysis and in vitro urolithiatic activity of Peltophorum pterocarpum leaves (DC) baker. J Med Plant Stud. 2016;18(43):18-22.

Kumar S, Shrivastava R, Bharadwaj M, Giridhar P, Prabhakaran M. Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells. J Fun Foods. 2015;15:509-515.

Makwana HT, Devkar RA, Setty MM. Evaluation of in vitro Antiurolithiatic potential of Bridelia retusa Spreng bark. Adv Sci Lett. 2017;23(3):1789-1791.

Mittal A, Tandon S, Singla S, Tandon C. In vitro studies reveal Anti-urolithiatic effect of Terminalia arjuna using quantitative morphological information from computerized microscopy. Int Braz J Urol. 2015;41(5):935-944.

Moir KW. The determination of oxalic acid in plants. Queenland J Agr Sci.1953;10:1-4.

Niharika M, Suchitha N, Akhila S, Himabindhu J, Ramananjaneyulu K. Evaluation ofin vitro activity of Gossypium Herbaceum J Pharma Sci Res . 2018;10(5):1236-1237.

Nandini BP, Sudarshana MSS, Rajashekar N. Assessment of antioxidant potentiality of leafy herbs subjecting to different cooking temperatures. Int J Cont Auto Sys. 2013;4(4):197-200.

Nirmala A,Saroja S, Gayathri Devi G. Antidiabetic Activity of Basella rubra and its relationship with the antioxidant Property. Brit Biotechnol J. 2011;1(1):1-9.

Obianime AW, Uche FI. The phytochemical screening and effects of methanolic extract of Phyllanthus amarus leaf on the biochemical parameters of male guinea pigs. J Appl Sci Environ Manage. 2008;12(4):73-77.

Prachi, Chauhan N, Kumar D, Kasana MS. Medicinal plants of Muzzaffarnagar district used in treatment of urinary tract and kidney stones. Indian J Trad Kn. 2009;8(2):191-195.

Romero V, Akpinar H, Assimos DG. Kidney stones: a global picture of prevalence, incidence, and associated risk factors. Rev Urol Spring Summer. 2010;12(2-3):86-96.

Ruch RJ, Cheng SJ, Klaunig JE. Prevention of cytotoxicity and inhibition of intracellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis. 1989;10(6):1003-1008.

Sahid-ud-daula AFM, Basher MA. Phytochemical screening, plant growth inhibition, and antimicrobial activity studies of Xylocarpus granatum Malaysian J Pharm Sci. 2009;7(1):9-21.

Shu-Mei L, Bo-Hong L, Wan-Mei H, Huey-Jiun K, Chi-Dong L, Lih-Geeng C, et al. Structural identification and bioactivities of red to violet pigments present in Basella alba Fruits. J Agric Food Chem. 2010;58(19):10364-10372.

Siriwatanametanon N, Fiebich BL, Efferth T, Prieto JM, Heinrich M. Traditionally used Thai medicinal plants: In vitro anti-inflammatory, anticancer and antioxidant activities. J Ethnopharmacol.2010;130(2):196-207.

Stamatelou KK, Francis ME, Jones CA, Nyberg LM, Curhan GC. Time trends in reported prevalence of kidney stones in the United States. Kidney Int. 2003;63(5):1817-1823.

Suresh HM, Vaishali M, Hugar DS, Sushrutha M. Evaluation of Punica grantum roots for Urolithiatic activity. J Pharm Chem. 2018;12(3):3-7.

Varicola KS, Siddiqua AA, Dintyala K, Ventrapati G. Fruit peel extracts with potential for dissolving simulated renal stones in in vitro conditions. Int J Pharm Sci. 2018;10(11):71-74.

Yachi L, Bennis S, Aliat Z, Cheikh A, Idrissi MOB, Draoui M. In vitro Litholytic activity of some medicinal plants on urinary stones. Afr J Urol. 2018;24(3):197-201.

YehLin L, Liu YH, Chyuan JH,Cheng KT, Liang WL, Hou WC, et al. Antioxidant activities of different wild bitter guard (Momordica charantia) cultivars. Bot Stud. 2012;53(2):207-214.

Zhong YS, Yu CH, Ying HZ, Wang ZY, Cai HF. Prophylactic effects of Orthosiphon stamineus Benth. extracts on experimental induction of calcium oxalate nephrolithiasis in rats. J Ethnopharmacol . 2012;144(3):761-767.

Downloads

Publicado

2023-02-17

Edição

Seção

Original Article

Como Citar

Inhibition of calculi forming oxalate by dietary Basella rubra organs: Litholytic activity. (2023). Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e20582

Dados de financiamento