The study of the biological activities of Ziziphora clinopodioides

Authors

  • Ulikhanyan Greta Yerevan State Medical University after M. Heratsi, Department of Pharmacognosy, Yerevan, Armenia
  • Beglaryan Margarita Yerevan State Medical University after M. Heratsi, Department of Pharmaceutical Management, Yerevan, Armenia
  • Poghosyan Gayane Yerevan State Medical University after M. Heratsi, Department of Medical Microbiology, Yerevan, Armenia
  • Shekoyan Vladimir Yerevan State Medical University after M. Heratsi, Department of Medical Microbiology, Yerevan, Armenia
  • Galstyan Hasmik Yerevan State Medical University after M. Heratsi, Department of Pharmacognosy, Yerevan, Armenia
  • Ananikyan Hrachya Scientific-Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences, Republic of Armenia
  • Ananikyan Violeta Scientific-Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences, Republic of Armenia
  • Goginyan Vigen Goginyan Vigen
  • Dumanyan Karine Yerevan State Medical University after M. Heratsi, Department of Pharmacognosy, Yerevan, Armenia
  • Ulikhanyan Ghukas Armenian Pharmaceutical Association, Yerevan, Armenia
  • Chichoyan Naira Yerevan State Medical University after M. Heratsi, Department of Pharmacognosy, Yerevan, Armenia

DOI:

https://doi.org/10.1590/s2175-97902022e19331

Keywords:

Ziziphora clinopodioides Lam, Essential oil, Antimicrobial activity, Antioxidant activity, DPPH, GC-MS, Kovats indices, IC50

Abstract

The aim of the current study was to determine the chemical constituents of essential oil and to study the antibacterial and antioxidant activities of essential oil and the extracts obtained from the raw material of Ziziphora wild growing in the floras of Armenia and Artsakh cultivated in the hydroponic conditions. The essential oils were obtained by the method of hydro-distillation. The determination of the essential oil constituents were performed by the GC-MS method. Agar disk diffusion method was used to study the antimicrobial activity of essential oils. The antioxidant activity determination was carried out DPPH test by the spectrophotometric method, at the same time IC50 was determined. The highest values of the essential oils yield (1.25 ± 0.01%) and IC50 13.83±0.218(x10-5)g/l) were received for the plant cultivated in hydroponic conditions. For the first time in the above studied samples, by the method of GC-MS more than 70 components were revealed. The results of the study showed that essential oils of Ziziphora exhibit antimicrobial activity and the extracts revealed relatively expressed antioxidant activity. The study results show the future prospects of the use of Ziziphora not only as the source of flavonoids and essential oils, but also antimicrobial and antioxidant agents.

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Published

2023-07-10

Issue

Vol. 58 (2022)

Section

Original Article

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How to Cite

The study of the biological activities of Ziziphora clinopodioides. (2023). Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e19331