Comparação do perfil imunohistoquímico entre mulheres com câncer de mama maiores de 40 e menores de 40 anos
DOI:
https://doi.org/10.11606/issn.1679-9836.v103i2e-210544Palavras-chave:
Neoplasias da mama, Carcinoma Ductal de mama, Carcinoma Lobular, Programas de RastreamentoResumo
Objetivo: Comparar os perfis imunohistoquímicos, incluindo marcadores substitutos da classificação molecular e descobertas histológicas de carcinomas mamários, de mulheres com menos e mais de 40 anos de idade. Métodos: Este foi um estudo observacional, quantitativo e retrospectivo baseado em dados do Instituto de Patologia de Araçatuba (IPAT), localizado no interior do estado de São Paulo, Brasil. Foram revisados os relatórios de patologia obtidos por biópsia ou excisão cirúrgica entre 1º de janeiro de 2017 e 30 de junho de 2020 (42 meses). Apenas carcinomas ductais e lobulares foram analisados histologicamente. Idade, subtipo molecular e dados imunohistoquímicos do receptor de estrogénio, receptor de progesterona, Her-2 e Ki-67 (< 20% x ≥ 20%) foram avaliados. Os espécimes foram divididos em dois grupos de acordo com a idade da paciente no momento do diagnóstico (≤40 anos x >40 anos). Resultados: Não houve diferença significativa entre os dois grupos etários em relação ao receptor hormonal, avaliação do HER-2, ou classificação histológica (ductal x lobular). No entanto, houve uma associação entre o grupo de mulheres mais jovens e um índice de Ki-67 mais elevado (p = 0,015). No grupo de mulheres com 40 anos de idade ou menos, metade dos casos foram classificados como Luminal B, HER-2 negativo, e 19% foram triplamente negativos. No grupo de mulheres com mais de 40 anos, 45% eram Luminal B, HER-2 negativo, 21% eram Luminal A, e apenas 13% eram triplo-negativos. Conclusão: A frequência do câncer da mama entre as mulheres jovens não é pequena e essa população tende a apresentar índices de Ki-67 mais elevados.
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Copyright (c) 2024 Thales Müller Silvério Alves, Rodrigo Justi Nogueira, Tony Maronesi Bagio, Mário Jefferson Quirino Louzada, Paulo Gil Katsuda, Deolino João Camilo-Júnior, José Cândido Caldeira Xavier-Júnior
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