Potencial terapêutico de fitoconstituintes de Pilocarpus microphyllus Stapf ex Wardlew. e da própolis na doença de Alzheimer: uma Revisão Integrativa
DOI:
https://doi.org/10.11606/issn.1679-9836.v103i2e-218782Palavras-chave:
Alzheimer, Jaborandi, Neuroproteção, Propolis, PilocarpinaResumo
Introdução: A doença de Alzheimer (DA) é uma enfermidade neurodegenerativa irreversível, caracterizada pela deterioração das funções cognitivas, cuja farmacoterapia disponível não é capaz de efetivar a cura. Objetivos: Averiguar as propriedades neuroprotetoras dos fitoconstituintes do Jaborandi (Pilocarpus microphyllus) e da própolis como possíveis agentes na terapêutica da DA. Metodologia: Trata-se de um estudo do tipo revisão integrativa da literatura, em que seguiu a estratégia PICO na formulação da pergunta norteadora. Utilizou-se cinco bases de dados: Pubmed, Web of Science, Scopus, Embase e Lilacs. A análise foi conduzida com os descritores “epiisopiloturine”, “episopilosin”, “pilocarpine”, “macaubine”, “propolis”, “alzheimer” extraídos do DeCS (Descritores em Ciências da Saúde) e do Medical Subject Headings (MeSH). As palavras-chave foram isoladas e combinadas entre si por meio dos operadores booleanos AND e OR. Resultados: A busca resultou em 602 estudos identificados nos bancos de dados, 337 eram duplicados, restando 265 para leitura do título e resumo, os quais 250 foram excluídos. Ao final, 10 estudos foram lidos na íntegra e 08 estudos incluídos no escopo da revisão. A pesquisa evidenciou atividade neuroprotetora para a própolis, através de ação antioxidativa, anti-inflamatória e anticolinesterásica, configurando-se com potencial terapêutico na DA. Para a pilocarpina, substância com diversas aplicabilidades clínicas, poucos trabalhos demonstraram correlação com a DA, na melhora cognitiva e de comportamento. Conclusão: Conclui-se, portanto, benefícios para o uso da própolis nas disfunções cognitivas, enquanto para a pilocarpina não se estabeleceu essa relação. Faz-se necessário o desenvolvimento de pesquisas que elucidem os possíveis papéis funcionais para essas substâncias.
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Copyright (c) 2024 José Gustavo Queiroz do Nascimento, Izadora, Francisco das Chagas Sousa Rocha, João Antônio Leal De Miranda; Maria Francilene Souza Silva, Jociane Sthefanny Tavares Silva
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Fundação de Amparo à Pesquisa do Estado do Piauí
Números do Financiamento 004/2022
