Can risk of sarcopenia predict poorer quality of life in hemodialysis patients?
DOI:
https://doi.org/10.1590/Keywords:
Chronic Kidney Failure, Hemodialysis, Quality of Life, SarcopeniaAbstract
Sarcopenia and low quality of life (QOL) are
widely found among hemodialysis (HD) patients. We aimed
to verify whether risk of sarcopenia can predict QOL level
in these patients. The sample included 147 patients with
chronic kidney disease undergoing HD in October 2020
at a single dialysis center. Demographic and clinical data
were collected. Risk of sarcopenia was classified using the
SARC-F questionnaire. QOL was evaluated by the Brazilian
version of the Short Form Health Survey (SF-36). QOL scores
were compared between patients with and without risk of
sarcopenia. Multivariate linear regression was performed
to test risk of sarcopenia as an independent predictor
of QOL scores. There were 62 (42.2%) patients with risk
of sarcopenia. In the comparison of QOL scores between
patients with and without risk of sarcopenia, scores of seven
dimensions were significantly lower among patients with
risk of sarcopenia, with the exception of the limitations
due to emotional problems. Risk of sarcopenia was an
independent predictor of six dimensions of QOL, except
for the role limitations due to emotional problems and
emotional well-being domains. We found risk of sarcopenia
to be an independent predictor of QOL among HD patients.
Our results point to the possibility of improving patients’
QOL by intervening to minimize the risk of sarcopenia.
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References
Menezes Neves PDM, Sesso RCC, Thomé FS, Lugon JR,
Nascimento MM. Brazilian dialysis census: analysis of data from
the 2009-2018 decade. Braz J Nephrol. 2020;42(2):191-200.
doi: 10.1590/2175-8239-jbn-2019-0234
Beaudart C, Biver E, Reginster JY, Rizzoli R, Rolland Y, et al.
Validation of the SarQoLâ, a specific health-related quality of
life questionnaire for sarcopenia. J Cachexia Sarcopenia Muscle.
;8(2):238-44. doi: 10.1002/jcsm.12149
Magalhães AM, Dias DA, Menezes KKP, Alves LC, Ferreira MCC,
Silva SF. Avaliação de força, independência e qualidade de vida
do paciente em hemodiálise. Rev Neurocienc. 2020;28:1-24.
Farias DH, Melo BC, Minatel V, Calles ACN, Lira JLF.
Sarcopenia e sua influência na mobilidade de pacientes com
doença renal crônica: uma revisão sistemática. Cons Saude.
;18(2):293-300. doi: 10.5585/ConsSaude.v18n2.10546
Tsekoura M, Kastrinis A, Katsoulaki M, Billis E, Gliatis J.
Sarcopenia and its impact on quality of life. Adv Exp Med
Biol. 2017;987:213-8. doi: 10.1007/978-3-319-57379-3_19
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, et al.
Sarcopenia: Revised European consensus on definition and
diagnosis. Age Ageing. 2019;48(1):16-31. doi: 10.1093/ageing/afy169
Sousa VA, Oliveira D, Mansur HN, Fernandes NMS, Bastos
MG. Sarcopenia in chronic kidney disease. Braz J Nephrol.
;37:98-105. doi: 10.5935/0101-2800.20150014
Foley RN, Wang C, Ishani A, Collins AJ, Murray AM. Kidney
function and sarcopenia in the United States general
population: NHANES III. Am J Nephrol. 2007;27(3):279-86.
doi: 10.1159/000101827
Santos PR. Qualidade de vida entre pacientes com doença
renal crônica em hemodiálise: seguimento de dois anos [tese].
Fortaleza: Universidade Federal do Ceará; 2009.
Mittal SK, Ahern L, Flaster E, Maesaka JK, Fishbane S.
Self-assessed physical and mental function of haemodialysis
patients. Nephrol Dial Transplant. 2001;16(7):1387-94. doi:
1093/ndt/16.7.1387
Jesus NM, Souza GF, Mendes-Rodrigues C, Almeida Neto
OP, Rodrigues DDM, Cunha CM. Quality of life of individuals
with chronic kidney disease on dialysis. Braz J Nephrol.
;41(3):364-74. doi: 10.1590/2175-8239-JBN-2018-0152
Associação Brasileira de Empresas e Pesquisa. Alterações na
aplicação do Critério Brasil. São Paulo: Associação Brasileira
de Empresas e Pesquisa; 2019.
Khan IH. Comorbidity: the major challenge for survival and
quality of life in end-stage renal disease. Nephrol Dial Transplant.
;13 Suppl:76-9. doi: 10.1093/ndt/13.suppl_1.76
Ciconelli RM, Ferraz MB, Santos W, Meinão I, Quaresma MR.
Tradução para a língua portuguesa e validação do questionário
genérico de avaliação de qualidade de vida SF-36 (Brasil
SF-36). Rev Bras Reumatol. 1999;39(3):143-50.
Malmstrom TK, Morley JE. SARC-F: A simple questionnaire
to rapidly diagnose sarcopenia. J Am Med Dir Assoc.
;14(8):531-2. doi: 10.1016/j.jamda.2013.05.018
Piotrowicz K, Głuszewska A, Czesak J, Fedyk-Łukasik M, Klimek E,
et al. SARC-F as a case-finding tool for sarcopenia according to the EWGSOP2. National validation and comparison with
other diagnostic standards. Aging Clin Exp Res. 2021;33:1821-9.
doi: 10.1007/s40520-020-01782-y
Teixeira VON, Filippin LI, Xavier RM. Mecanismos de perda
muscular da sarcopenia. Rev Bras Reumatol. 2012;52(2):247-59.
Moorthi RN, Avin KG. Clinical relevance of sarcopenia in chronic
kidney disease. Curr Opin Nephrol Hypertens. 2017;26(3):219-28.
doi: 10.1097/MNH.0000000000000318
Pardo FL. Sarcopenia em pacientes idosos com doença
renal crônica em hemodiálise [dissertação]. Rio de Janeiro:
Universidade do Estado do Rio de Janeiro; 2012.
Silva Neto LS, Karnikowiski MGO, Tavares AB, Lima RM.
Association between sarcopenia, sarcopenic obesity, muscle
strength and quality of life variables in elderly women. Braz J Phys
Ther. 2012;16(5):360-7. doi: 10.1590/S1413-35552012005000044
Kull M, Kallikorm R, Lember M. Impact of a new sarco-osteopenia
definition on health-related quality of life in a population-based
cohort in Northern Europe. J Clin Densitom. 2012;15(1):32-8.
doi: 10.1016/j.jocd.2011.08.007
Chuasuwan A, Pooripussarakul S, Thakkinstian A, Ingsathit A,
Pattanaprateep O. Comparisons of quality of life between
patients underwent peritoneal dialysis and hemodialysis:
a systematic review and meta-analysis. Health Qual Life
Outcomes. 2020;18:1-11. doi: 10.1186/s12955-020-01449-2
Chen JY, Wan EYF, Choi EPH, Chan AKC, Chan KHY,
et al. The health-related quality of life of Chinese patients
on hemodialysis and peritoneal dialysis key points for
decision makers. Patient. 2017;10(6):799-808. doi: 10.1007/
s40271-017-0256-6
Gonçalves FA, Dalosso IF, Borba JMC, Bucaneve J, Valerio NMP,
et al. Quality of life in chronic renal patients on hemodialysis
or peritoneal dialysis: a comparative study in a referral
service of Curitiba - PR. J Braz Nephrol. 2015;37(4):467-74.
doi: 10.5935/0101-2800.20150074
Czyżewski Ł, Sańko-Resmer J, Wyzgał J, Kurowski A.
Assessment of health-related quality of life of patients after
kidney transplantation in comparison with hemodialysis and
peritoneal dialysis. Ann Transplant. 2014;19(1):576-85. doi:
12659/AOT.891265
Hernandez HJ, Obamwonyi G, Harris-Love MO. Physical Therapy
Considerations for Chronic Kidney Disease and Secondary
Sarcopenia. J Funct Morphol Kinesiol. 2018;3(1):1-12. doi:
3390/jfmk3010005
Yu R, Chen J, Xu J, Cao J, Wang Y, et al. Supression of muscle
wasting by the plant-derived compound ursolic acid in a model
of chronic kidney disease. J Cachexia Sarcopenia Muscle.
;8(2):327-41. doi: 10.1002/jcsm.12162
Chatzipetrou V, Bégin MJ, Hars M, Trombetti A. Sarcopenia
in chronic kidney disease: a scoping review of prevalence,
risk factors, association with outcomes and treatment. Calcif
Tissue Int. 2022 Jan;110(1):1-31. doi: 10.1007/s00223-021-00898-1
Watanabe H, Enoki Y, Maruyama T. Sarcopenia in chronic kidney
disease: factors, mechanisms and therapeutic interventions.
Biol Pharm Bull. 2019;42(9):1437-45. doi: 10.1248/bpb.b19-00513
Ikizler TA, Cano NJ, Franch H, Fouque D, Himmelfarb J,
et al. Prevention and treatment of protein energy wasting in
chronic kidney disease patients: a consensus statement by
the International Society of Renal Nutrition and Metabolism.
Kidney Int. 2013;84(6):1096-107. doi: 10.1038/ki.2013.147
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Copyright (c) 2024 Paulo Roberto Santos, Sâmia Marques Lourenço Landim, Kailane Martins Cardoso, Luciana Abreu Sousa, Victor Lavinas Santos
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