Histochemical studies of the cardiac lipofuscin in the heart of men and dogs related to age

Abstract

Lipofuscin pigments were first detected in the heart of 10 years old humans and in dogs of eighteen months of age. The highest concentration of this type of pigment in the heart of dogs was observed in animals from 6-8 years of age and seems to have no quantitative or qualitative correlation to pathologic processes. From the histochemical point of view the main difference observed is related to the PAS reactivity of the pigment which was negative in humans over 60 years of age and positive in all the different age groups of dogs examined.