Progressão da Esclerose Múltipla Remitente-Recorrente apesar da nova era de medicamentos
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2022.196823Palavras-chave:
Esclerose múltipla, Progressão de doença, TerapiasResumo
Objetivo. O presente estudo tem como objetivo avaliar as condições associadas à progressão de doença e disfunções dos pacientes com Esclerose Múltipla (EM). Métodos. Estudo observacional analítico longitudinal retrospectivo com 46 pacientes com EM de uma policlínica do Rio de Janeiro, Brasil. Foi utilizada a Escala de Incapacidade Funcional Expandida (EDSS) para classificar os pacientes de acordo com a incapacidade e estabelecer correlação com fatores de risco, tratamento e tempo de doença. Resultados. Dos 46 pacientes, 69,6% eram do sexo feminino e 67,4% eram brancos. Pacientes com menos sistemas funcionais afetados no início da EM levaram maior tempo para progressão da doença. Medicamentos de baixa eficácia foram associados a uma alta taxa de descontinuação do tratamento. Pacientes em tratamento contínuo levaram maior tempo para atingir valores mais altos de EDSS comparado com pacientes que descontinuaram o tratamento. Conclusão. Apesar do controle da EM com medicamentos de alta eficácia, os pacientes ainda apresentam alguma incapacidade. Os fatores que influenciaram a progressão da incapacidade foram: múltiplos sintomas no início da doença, mais de 30 anos no início da EM, atraso no diagnóstico e início do tratamento, entre outros.
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Copyright (c) 2022 Gutemberg Augusto Cruz dos Santos, Gabriel Etienne Brito de Salles, Milenna Grisoli Martins da Silva, Roxanne Cabral Pinto Santos
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
