Control epigenético de las drogas de abuso: ¿nueva contribución a la salud mental?

Autores/as

DOI:

https://doi.org/10.11606/issn.1806-6976.smad.2024.216898

Palabras clave:

Vulnerabilidad en Salud, Trastornos Relacionados con Sustancias, Salud Mental, Epigenómica

Resumen

Objetivo: mapear la producción de conocimiento sobre el papel de la epigenética en respuesta
a las drogas de abuso, así como los cambios epigenéticos observados en la adicción y la salud
mental. Metodología: se realizó una revisión del alcance. La búsqueda se realizó en las bases
de datos bibliográficas: PubMed/Medline, Science Direct, Scopus, Bentham Science, Embase,
Web of Science y Gale Academic OneFile. Los datos generados fueron analizados temáticamente
en tres etapas: a) selección y análisis de artículos; b) análisis de datos textuales; c) generación de
mapas bibliográficos. Resultados: la búsqueda identificó 21 artículos relacionados con los efectos
epigenéticos de las drogas de abuso sobre los mecanismos que generan dependencia química.
Conclusión: los resultados obtenidos permitieron identificar y verificar que los mecanismos
epigenéticos ocurren en respuesta al uso de drogas de abuso, resultando así en cambios en la
expresión genética. Se señala que la epigenética pretende ofrecer un mecanismo adicional de
control sobre la transcripción y cómo se expresan los genes, buscando mitigar el impacto de las
drogas de abuso en el tratamiento de los trastornos mentales y la dependencia química.

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Biografía del autor/a

  • Aldo Pacheco Ferreira, Escola Nacional de Saúde Pública Sergio Arouca, Departamento de Estudos sobre Violência e Saúde Jorge Careli, Rio de Janeiro, RJ, Brasil.

    Bacharel em Ciências Biológicas (UGF), Mestrado e Doutorado em Engenharia Biomédica (Coordenação dos Programas de Pós-graduação em Engenharia - COPPE, Universidade Federal do Rio de janeiro - /UFRJ). Pesquisador e Docente da Escola Nacional de Saúde Pública Sergio Arouca/FIOCRUZ, lotado no Departamento de Direitos Humanos, Saúde e Diversidade Cultural. Tem experiência na área de Saúde Pública, com ênfase em Saúde Coletiva, atuando como professor, pesquisador e orientador principalmente nos seguintes temas: Toxicologia e saúde; Metodologia de pesquisa em saúde pública, Violência e saúde; Saúde e trabalho; Construção do conhecimento epidemiológico aplicado as práticas de saúde; Direitos humanos; Saúde mental; Direitos humanos, saúde e cidadania; Saúde coletiva. Pesquisador 1-D (CNPq).

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Publicado

2024-07-05

Cómo citar

Ferreira, A. P., & Cruz-Hernández, M. J. (2024). Control epigenético de las drogas de abuso: ¿nueva contribución a la salud mental?. SMAD, Revista Eletrônica Saúde Mental Álcool E Drogas (Edição Em Português), 20, e-216898. https://doi.org/10.11606/issn.1806-6976.smad.2024.216898