Nonsteroidal antiinflammatory drugs and their local pharmacology
DOI:
https://doi.org/10.11606/issn.2317-0190.v16i4a103285Keywords:
Pharmacology, Anti-Inflammatory Agents, Non-Steroidal, Wounds and Injuries/rehabilitationAbstract
Non-steroidal anti-inflammatory drugs (NSAIDS) are often used to reduce pain and inflammation from various types of injuries. Although these drugs are usually orally taken, localized administration has attracted the attention of medical professionals and researchers interested in proving the enhanced availability of these medicines close to the injuries. This review briefly analyzes the localized therapy, especially the intradermal one, as a promising alternative to the administration of NSAIDS.
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References
Insel PA. Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Gilman AG, Limbird LE. Goodman & Gilman's. The pharmacological basis of therapeutics. 11th ed. New York: McGraw-Hill; 2005. p. 2021.
Serhan CN, Chiang N. Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics. Rheum Dis Clin North Am. 2004;30(1):69-95.
Rang HP, Dale MM, Ritter JM, Flower RJ. Farmacologia com student consult. 6th ed. Rio de Janeiro: Elsevier; 2007.
Serhan CN, Oliw E. Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways. J Clin Invest. 2001;107(12):1481-9.
Fu JY, Masferrer JL, Seibert K, Raz A, Needleman P. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem. 1990;265(28):16737-40.
Chou R, Helfand M, Peterson K, Dana T, Roberts C. Drug Class Review on Cyclooxygenase (COX)-2 Inhibitors and Non-steroidal Anti-inflammatory Drugs (NSAIDs). Portland: Oregon Health & Science University; 2006.
Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/ antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002;99(21):13926-31.
Davies NM, Good RL, Roupe KA, Yáñez JA. Cyclooxygenase-3: axiom, dogma, anomaly, enigma or splice error?--Not as easy as 1, 2, 3. J Pharm Pharm Sci. 2004;7(2):217-26.
Feldman M, McMahon AT. Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal anti-inflammatory drugs, with less gastrointestinal toxicity? Ann Intern Med. 2000;132(2):134-43.
Berenbaum F. New horizons and perspectives in the treatment of osteoarthritis. Arthritis Res Ther. 2008;10 Suppl 2:S1-7.
Weideman RA, Kelly KC, Kazi S, Cung A, Roberts KW, Smith HJ, et al. Risks of clinically significant upper gastrointestinal events with etodolac and naproxen: a historical cohort analysis. Gastroenterology. 2004;127(5):1322-8.
Goldkind L, Laine L. A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience. Pharmacoepidemiol Drug Saf. 2006;15(4):213-20.
Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med. 2005;352(11):1092-102.
Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, et al. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med. 2005;352(11):1071-80.
Solignac M. Assessment of a topical NSAIDs in the treatment of pain and inflammation. The example of Flector Plaster, a local bioadhesive plaster containing diclofenac epolamine. Presse Med. 2004;33(14 Pt 2):3S10-3.
Petersen B, Rovati S. Diclofenac epolamine (Flector) patch: evidence for topical activity. Clin Drug Investig. 2009;29(1):1-9.
Sarigüllü Ozgüney I, Yeşim Karasulu H, Kantarci G, Sözer S, Güneri T, Ertan G. Transdermal delivery of diclofenac sodium through rat skin from various formulations. AAPS PharmSciTech. 2006;7(4):88.
McNeill SC, Potts RO, Francoeur ML. Local enhanced topical delivery (LETD) of drugs: does it truly exist? Pharm Res. 1992;9(11):1422-7.
Higaki K, Asai M, Suyama T, Nakayama K, Ogawara K, Kimura T. Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer. Int J Pharm. 2002;239(1-2):129-41.
Higaki K, Nakayama K, Suyama T, Amnuaikit C, Ogawara K, Kimura T. Enhancement of topical delivery of drugs via direct penetration by reducing blood flow rate in skin. Int J Pharm. 2005;288(2):227-33.
Zacher J, Altman R, Bellamy N, Brühlmann P, Da Silva J, Huskisson E, et al. Topical diclofenac and its role in pain and inflammation: an evidence-based review. Curr Med Res Opin. 2008;24(4):925-50.
Heyneman CA, Lawless-Liday C, Wall GC. Oral versus topical NSAIDs in rheumatic diseases: a comparison. Drugs. 2000;60(3):555-74.
Russell AL. Piroxicam 0.5% topical gel compared to placebo in the treatment of acute soft tissue injuries: a double-blind study comparing efficacy and safety. Clin Invest Med. 1991;14(1):35-43.
Brühlmann P, de Vathaire F, Dreiser RL, Michel BA. Short-term treatment with topical diclofenac epolamine plaster in patients with symptomatic knee osteoarthritis: pooled analysis of two randomised clinical studies. Curr Med Res Opin. 2006;22(12):2429-38.
Joussellin E. Flector Tissugel® in the treatment of painful ankle sprain. J Traumatol Sport. 2003;20:1S5-9.
Petersen B, Rovati S. Diclofenac epolamine (Flector) patch: evidence for topical activity. Clin Drug Investig. 2009;29(1):1-9.
Mazières B, Rouanet S, Velicy J, Scarsi C, Reiner V. Topical ketoprofen patch (100 mg) for the treatment of ankle sprain: a randomized, double-blind, placebo-controlled study. Am J Sports Med. 2005;33(4):515-23.
Esparza F, Cobián C, Jiménez JF, García-Cota JJ, Sánchez C, Maestro A, et al. Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries. Br J Sports Med. 2007;41(3):134-9.
Lundell JC, Silverman DG, Brull SJ, O'Connor TZ, Kitahata LM, Collins JG, et al. Reduction of postburn hyperalgesia after local injection of ketorolac in healthy volunteers. Anesthesiology. 1996;84(3):502-9.
Dogrul A, Gülmez SE, Deveci MS, Gul H, Ossipov MH, Porreca F, et al. The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. Anesth Analg. 2007;104(4):927-35.
Pistor M. What is mesotherapy. Chir Dent Fr. 1976;46(288):59-60.
Corbel D. Initiation à l' ID-thérapie mésothérapie. Paris: SIMEP; 1989.
Metsavaht L, Metsavaht O, Knackfuss I, De Gervais J. Mesoterapia para o tratamento da epicondilite lateral no cotovelo. Med Reabil. 1998;48:23-6.
Metsavaht L, Metsavaht O, Neto VG, Knackfuss, I. Mesoterapia nas tedinites do maguito dos rotadores do ombro. Med Reabil. 1999;50:17-22.
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