Testosterona e acidente vascular encefálico isquêmico
DOI:
https://doi.org/10.11606/issn.2317-0190.v25i3a162587Palavras-chave:
Acidente Vascular Cerebral, Androgênios, Testosterona, ReabilitaçãoResumo
Níveis de testosterona sérica já foram relacionados a piora de fatores hematológicos, função e envelhecimento vascular, contribuindo potencialmente para formação de trombos. Com o envelhecimento, dados epidemiológicos mostram declínio dos níveis de testosterona, prejuízo da função vascular e aumento das incidências de doenças vasculares, como o AVE. Objetivo: Descrever estudos que abordaram a potencial relação dos níveis de testosterona com a prevenção, apresentação clínica e prognóstico do AVE. Métodos: Uma pesquisa e seleção de artigos foi conduzida em três diferentes bases de dados (MEDLINE, SCIELO, LILACS) utilizando termos relacionados a testosterona e AVE (inglês e português), filtrada para estudos em humanos. Apenas estudos que abordaram algum aspecto da relação entre testosterona e AVE foram incluídos para discussão no presente estudo. Resultados: A busca resultou em 12 estudos relevantes para análise e discussão (7 observacionais, 3 transversais, 2 experimentais). Estudos observacionais verificaram um papel protetor da testosterona na incidência de AVE. Estudos transversais verificaram alterações endocrinológicas, como o hipogonadismo, na fase aguda do AVE, bem como melhor apresentação clínica (gravidade, tamanho da lesão). Estudos experimentais controlados verificaram benefícios clínicos e funcionais da suplementação de testosterona em pacientes em reabilitação. Conclusão: Apesar dos potenciais diversos benefícios destacados de níveis mais altos de testosterona no AVE, mais estudos que abordem de forma sistematizada o papel da testosterona em aspectos preventivos, de apresentação clínica, e de reabilitação e prognóstico serão bem vindos, para melhor manejo e otimização do tratamento do AVE.
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