Correlações epigenéticas do câncer de boca e da doença periodontal
DOI:
https://doi.org/10.11606/issn.2357-8041.clrd.2021.187977Palavras-chave:
Doença periodontal, Carcinoma oral de células escamosas, Câncer, Epigenética, Metilação, HistonaResumo
O objetivo deste artigo foi revisar a literatura em busca de possíveis inter-relações entre as alterações epigenéticas no câncer e na doença periodontal, alertando sobre uma potencial plausibilidade biológica. Para isso, realizou-se uma revisão narrativa da literatura por meio de uma pesquisa nas bases de dados LILACS, PubMed e SciELO pelos descritores “Epigenetic AND Periodontal disease”, “Epigenetic AND Oral cancer”, e “Epigenetic AND Periodontal disease AND Oral cancer”. A partir dessa busca, foram selecionados 56 artigos sobre o tema. As evidências científicas demonstram que a inflamação crônica ocasionada pela presença das bactérias periodontopatogênicas no biofilme dental é capaz de produzir modificações epigenéticas, como metilação do DNA e modificações de histonas. Essas alterações podem inibir genes supressores de tumor e ativar oncogenes, que contribuem para o desenvolvimento e a progressão do câncer de boca. Portanto, há indícios de que o mecanismo fisiopatológico envolvido nas alterações epigenéticas no câncer e na doença periodontal são semelhantes. Conclui-se que existe uma relação positiva entre essas duas doenças, sugerindo que a doença periodontal pode ser um potencial fator de risco para o câncer de boca.
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Referências
Ari G, Cherukuri S, Namasivayam A. Epigenetics and Periodontitis: A Contemporary Review. J Clin Diagn Res. 2016;10(11):ZE07-9. Doi: https://doi.org/10.7860/JCDR/2016/21025.8864
Moergel M, Kämmerer P, Kasaj A, Armouti E, Alshihri A, Weyer V, et al. Chronic periodontitis and its possible association with oral squamous cell carcinoma – a retrospective case control study. Head Face Med. 2013;9:39. Doi: https://doi.org/10.1186/1746-160X-9-39
Yao QW, Zhou DS, Peng HJ, Ji P, Liu DS. Association of periodontal disease with oral cancer: a meta-analysis. Tumour Biol. 2014;35(7):7073-7. Doi: https://doi.org/10.1007/s13277-014-1951-8
Michaud DS, Fu Z, Shi J, Chung M. Periodontal Disease, Tooth Loss, and Cancer Risk. Epidemiol Rev. 2017;39(1):49-58. Doi: https://doi.org/10.1093/epirev/mxx006
Fabri GM, Siqueira SR, Simione C, Nasri C, Teixeira MJ, Siqueira JT. Refractory craniofacial pain: is there a role of periodontal disease as a comorbidity? Arq Neuropsiquiatr. 2009;67(2B):474-9. Doi: https://doi.org/10.1590/s0004-282x2009000300018
Fabri GM, Pereira RM, Savioli C, Saad CG, Moraes JC, Siqueira JT, et al. Periodontitis Response to Anti-TNF Therapy in Ankylosing Spondylitis. J Clin Rheumatol. 2015;21(7):341-5. Doi: https://doi.org/10.1097/RHU.0000000000000300
Fabri GMC. Potential Link between COVID-19 and Periodontitis: Cytokine Storm, Immunosuppression, and Dysbiosis. Oral Health Dent Manag. 2020;20(1):1-5.
Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020: incidência de câncer no Brasil. Rio de Janeiro: INCA; 2019.
Díez-Pérez R, Campo-Trapero J, Cano-Sánchez J, López-Durán M, Gonzalez-Moles MA, Bascones-Ilundain J, et al. Methylation in oral cancer and pre-cancerous lesions (Review). Oncol Rep. 2011;25(5):1203-9. Doi: https://doi.org/10.3892/or.2011.1205
Ha PK, Califano JA. Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol. 2006;7(1):77-82. Doi: https://doi.org/10.1016/S1470-2045(05)70540-4
Bromberg J, Wang TC. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell. 2009;15(2):79-80. Doi: https://doi.org/10.1016/j.ccr.2009.01.009
Feller L, Altini M, Lemmer J. Inflammation in the context of oral cancer. Oral Oncol. 2013;49(9):887-92. Doi: https://doi.org/10.1016/j.oraloncology.2013.07.003
Murata M. Inflammation and cancer. Environ Health Prev Med. 2018;23(1):50. Doi: https://doi.org/10.1186/s12199-018-0740-1
Kundu JK, Surh YJ. Inflammation: gearing the journey to cancer. Mutat Res. 2008;659(1-2):15-30. Doi: https://doi.org/10.1016/j.mrrev.2008.03.002
Moore MM, Chua W, Charles KA, Clarke SJ. Inflammation and cancer: causes and consequences. Clin Pharmacol Ther. 2010;87(4):504-8. Doi: https://doi.org/10.1038/clpt.2009.254
Barros SP, Fahimipour F, Tarran R, Kim S, Scarel-Caminaga RM, Justice A, et al. Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesis. Periodontol 2000. 2020;82(1):157-72. Doi: https://doi.org/10.1111/prd.12322
Javed F, Warnakulasuriya S. Is there a relationship between periodontal disease and oral cancer? A systematic review of currently available evidence. Crit Rev Oncol Hematol. 2016;97:197-205. Doi: https://doi.org/10.1016/j.critrevonc.2015.08.018
Li S, Liu X, Zhou Y, Acharya A, Savkovic V, Xu C, et al. Shared genetic and epigenetic mechanisms between chronic periodontitis and oral squamous cell carcinoma. Oral Oncol. 2018;86:216-24. Doi: https://doi.org/10.1016/j.oraloncology.2018.09.029
Ye L, Jiang Y, Liu W, Tao H. Correlation between periodontal disease and oral cancer risk: A meta-analysis. J Cancer Res Ther. 2016;12(Suppl):C237-40. Doi: https://doi.org/10.4103/0973-1482.200746
Stuani VT, Sant’Ana ACP, Soares LAV Jr, Santos PSS. A relação entre doença periodontal e o câncer oral. Rev Bras Odontol. 2016;73(3):218-22.
Saleh R, Toor SM, Sasidharan Nair V, Elkord E. Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression. Front Immunol. 2020;11:1469. Doi: https://doi.org/10.3389/fimmu.2020.01469
Adcock IM, Tsaprouni L, Bhavsar P, Ito K. Epigenetic regulation of airway inflammation. Curr Opin Immunol. 2007;19(6):694-700. Doi: https://doi.org/10.1016/j.coi.2007.07.016
Irimie AI, Ciocan C, Gulei D, Mehterov N, Atanasov AG, Dudea D, et al. Current Insights into Oral Cancer Epigenetics. Int J Mol Sci. 2018;19(3):670. Doi: https://doi.org/10.3390/ijms19030670
Khouly I, Braun RS, Ordway M, Aouizerat BE, Ghassib I, Larsson L, et al. The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review. Int J Mol Sci. 2020;21(17):6217. Doi: https://doi.org/10.3390/ijms21176217
Seo JY, Park YJ, Yi YA, Hwang JY, Lee IB, Cho BH, et al. Epigenetics: general characteristics and implications for oral health. Restor Dent Endod. 2015;40(1):14-22. Doi: https://doi.org/10.5395/rde.2015.40.1.14
Gomez RS, Dutra WO, Moreira PR. Epigenetics and periodontal disease: future perspectives. Inflamm Res. 2009;58(10):625-9. Doi: https://doi.org/10.1007/s00011-009-0041-7
Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M, et al. Oral cancer: A multicenter study. Med Oral Patol Oral Cir Bucal. 2018;23(1):e23-9. Doi: https://doi.org/10.4317/medoral.21999
Barros SP, Hefni E, Nepomuceno R, Offenbacher S, North K. Targeting epigenetic mechanisms in periodontal diseases. Periodontol 2000. 2018;78(1):174-84. Doi: https://doi.org/10.1111/prd.12231
Williams SD, Hughes TE, Adler CJ, Brook AH, Townsend GC. Epigenetics: a new frontier in dentistry. Aust Dent J. 2014;59(1 Suppl):23-33. Doi: https://doi.org/10.1111/adj.12155
Barros SP, Offenbacher S. Modifiable risk factors in periodontal disease: epigenetic regulation of gene expression in the inflammatory response. Periodontol 2000. 2014;64(1):95-110. Doi: https://doi.org/10.1111/prd.12000
Bobetsis YA, Barros SP, Lin DM, Weidman JR, Dolinoy DC, Jirtle RL, et al. Bacterial infection promotes DNA hypermethylation. J Dent Res. 2007;86(2):169-74. Doi: https://doi.org/10.1177/154405910708600212
Zhang S, Barros SP, Niculescu MD, Moretti AJ, Preisser JS, Offenbacher S. Alteration of PTGS2 promoter methylation in chronic periodontitis. J Dent Res. 2010;89(2):133-7. Doi: https://doi.org/10.1177/0022034509356512
Martins MD, Jiao Y, Larsson L, Almeida LO, Garaicoa-Pazmino C, Le JM, et al. Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016;95(2):215-22. Doi: https://doi.org/10.1177/0022034515611876
Offenbacher S, Barros SP, Singer RE, Moss K, Williams RC, Beck JD. Periodontal disease at the biofilm-gingival interface. J Periodontol. 2007;78(10):1911-25. Doi: https://doi.org/10.1902/jop.2007.060465
Zhang S, Barros SP, Moretti AJ, Yu N, Zhou J, Preisser JS, et al. Epigenetic regulation of TNFA expression in periodontal disease. J Periodontol. 2013;84(11):1606-16. Doi: https://doi.org/10.1902/jop.2013.120294
Duarte PM, Rocha M, Sampaio E, Mestnik MJ, Feres M, Figueiredo LC, et al. Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study. J Periodontol. 2010;81(7):1056-63. Doi: https://doi.org/10.1902/jop.2010.090732
Andia DC, Oliveira NF, Casarin RC, Casati MZ, Line SR, Souza AP. DNA methylation status of the IL8 gene promoter in aggressive periodontitis. J Periodontol. 2010;81(9):1336-41. Doi: https://doi.org/10.1902/jop.2010.100082
Offenbacher S, Barros SP, Beck JD. Rethinking periodontal inflammation. J Periodontol. 2008;79(8 Suppl):1577-84. Doi: https://doi.org/10.1902/jop.2008.080220
Zhang S, Crivello A, Offenbacher S, Moretti A, Paquette DW, Barros SP. Interferon-gamma promoter hypomethylation and increased expression in chronic periodontitis. J Clin Periodontol. 2010;37(11):953-61. Doi: https://doi.org/10.1111/j.1600-051X.2010.01616.x
Bascones-Martínez A, Muñoz-Corcuera M, Noronha S, Mota P, Bascones-Ilundain C, Campo-Trapero J. Host defence mechanisms against bacterial aggression in periodontal disease: Basic mechanisms. Med Oral Patol Oral Cir Bucal. 2009;14(12):e680-5. Doi: https://doi.org/10.4317/medoral.14.e680
Loos BG, Van Dyke TE. The role of inflammation and genetics in periodontal disease. Periodontol 2000. 2020;83(1):26-39. Doi: https://doi.org/10.1111/prd.12297
Martino DJ, Prescott SL. Silent mysteries: epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease. Allergy. 2010;65(1):7-15. Doi: https://doi.org/10.1111/j.1398-9995.2009.02186.x
Cantley MD, Bartold PM, Marino V, Fairlie DP, Le GT, Lucke AJ, et al. Histone deacetylase inhibitors and periodontal bone loss. J Periodontal Res. 2011;46(6):697-703. Doi: https://doi.org/10.1111/j.1600-0765.2011.01392.x
Larsson L. Current Concepts of Epigenetics and Its Role in Periodontitis. Curr Oral Health Rep. 2017;4(4):286-93. Doi: https://doi.org/10.1007/s40496-017-0156-9
Kim TI, Han JE, Jung HM, Oh JH, Woo KM. Analysis of histone deacetylase inhibitor-induced responses in human periodontal ligament fibroblasts. Biotechnol Lett. 2013;35(1):129-33. Doi: https://doi.org/10.1007/s10529-012-0992-6
Sufaru IG, Beikircher G, Weinhaeusel A, Gruber R. Inhibitors of DNA methylation support TGF-β1-indiced IL11 expression in gingival fibroblasts. J Periodontal Implant Sci. 2017;47(2):66-76. Doi: https://doi.org/10.5051/jpis.2017.47.2.66
Radhakrishnan R, Kabekkodu S, Satyamoorthy K. DNA hypermethylation as an epigenetic mark for oral cancer diagnosis. J Oral Pathol Med. 2011;40(9):665-76. Doi: https://doi.org/10.1111/j.1600-0714.2011.01055.x
Baba S, Hara A, Kato K, Long NK, Hatano Y, Kimura M, et al. Aberrant promoter hypermethylation of the CHFR gene in oral squamous cell carcinomas. Oncol Rep. 2009;22(5):1173-9. Doi: https://doi.org/10.3892/or_00000552
Viet CT, Jordan RC, Schmidt BL. DNA promoter hypermethylation in saliva for the early diagnosis of oral cancer. J Calif Dent Assoc. 2007;35(12):844-9.
Youssef EM, Lotan D, Issa JP, Wakasa K, Fan YH, Mao L, et al. Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis. Clin Cancer Res. 2004;10(5):1733-42. Doi: https://doi.org/10.1158/1078-0432.ccr-0989-3
Kudo Y, Kitajima S, Ogawa I, Hiraoka M, Sargolzaei S, Keikhaee MR, et al. Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin. Clin Cancer Res. 2004;10(16):5455-63. Doi: https://doi.org/10.1158/1078-0432.CCR-04-0372
Rokavec M, Öner MG, Hermeking H. Inflammation-induced epigenetic switches in cancer. Cell Mol Life Sci. 2016;73(1):23-39. Doi: https://doi.org/10.1007/s00018-015-2045-5
Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349(21):2042-54. Doi: https://doi.org/10.1056/NEJMra023075
Tasoulas J, Giaginis C, Patsouris E, Manolis E, Theocharis S. Histone deacetylase inhibitors in oral squamous cell carcinoma treatment. Expert Opin Investig Drugs. 2015;24(1):69-78. Doi: https://doi.org/10.1517/13543784.2014.952368
Tan W, Zhou W, Yu HG, Luo HS, Shen L. The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo. Biochem Biophys Res Commun. 2013;430(1):250-5. Doi: https://doi.org/10.1016/j.bbrc.2012.10.143
Zeng XQ, Wang J, Chen SY. Methylation modification in gastric cancer and approaches to targeted epigenetic therapy (Review). Int J Oncol. 2017;50(6):1921-33. Doi: https://doi.org/10.3892/ijo.2017.3981
Tâlvan ET, Mohor C, Chisnoiu D, Cristea V, Câmpian RS. Expression of interleukin (IL)-1β, IL-8, IL-10 and IL-13 in Chronic Adult Periodontitis Progression. Arch Med (Oviedo). 2017;9(3):4.
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Copyright (c) 2021 Amanda Hastenreiter Costa Dornelas , Karla de Andrade Luiz, Victória Boechat Feyo, Yuri de Lima Medeiros, Ana Carolina Alves Pereira, Raissa Caputo de Azevedo, Gisele Maria Campos Fabri
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