Chronic kidney disease as an aggravating factor in dengue virus infection

Autores/as

DOI:

https://doi.org/10.11606/issn.2176-7262.rmrp.2024.213689

Palabras clave:

Dengue, Severe dengue, Kidney diseases, Mortality, Fatal outcome

Resumen

Background: Dengue virus infection is a public health problem worldwide, which can manifest from a mild febrile condition to severe disease, with multiple organ involvement, including kidney disease. The aim of this study was to analyze the most recent cases of dengue in the pre-COVID-19 era, assessing how chronic kidney disease (CKD) aggravates its clinical manifestations. Methods: A cross-sectional study was carried out using the database of the Health Secretariat of the state of Ceará, northeastern Brazil, in the period from January 2015 to December 2017. A comparison was made between patients with and without CKD. Results: A total of 161,880 patients were included. Patients with CKD were older (41±22 vs. 35±21 years, p<0.001), predominantly female (62 vs. 57%, p=0.004) and had a higher frequency of certain symptoms and signs. However, the only warning sign that was more prevalent among CKD patients was lethargy (0.5% vs. 0.004%, p=004). The most common comorbidities were hypertension and diabetes, which are also the most common causes of CKD (51 vs. 3.3% / 42 vs. 1.3%, p<0.001). Need for hospitalization was significantly more frequent in the group with CKD (12.3% vs. 2.2%, p<0.001), with mortality being higher in CKD patients (2.2% vs. 0.1%, p<0.001). Independent risk factors for death were: age, vomiting, leukopenia, diabetes, CKD and hypertension. Conclusions: CKD aggravates dengue severity, and people with this comorbidity should be carefully monitored, especially in epidemic periods.

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Biografía del autor/a

  • Geraldo Bezerra Silva Junior, Universidade de Fortaleza, Programa de Pós-Graduação em Saúde Coletiva, Fortaleza, (CE), Brasil

    PhD, Full Professor.

  • Ana Amélia Reis Jereissati, Universidade de Fortaleza, Programa de Pós-Graduação em Saúde Coletiva, Fortaleza, (CE), Brasil

    PhD, Assistant Professor.

  • José Reginaldo Pinto, Faculdade Luciano Feijão. Faculdade de Odontologia, Sobral, (CE), Brasil

    PhD, Assistant Professor.

  • Rodrigo Tavares Dantas, Universidade de Fortaleza, Programa de Pós-Graduação em Saúde Coletiva, Fortaleza, (CE), Brasil

    PhD, Post-graduate Studant, Nurse Assistant.

  • Janaína de Almeida Mota Ramalho, Universidade de Fortaleza, Faculdade de Medicina, Fortaleza, (CE), Brasil

    PhD, Assistant Professor.

  • Gdayllon Cavalcante Meneses, Universidade Federal do Ceará. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas, Fortaleza, (CE), Brasil

    PhD, Post-graduate Studant.

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Publicado

2024-12-27

Número

Vol. 57 Núm. 3 (2024)

Sección

Artigo Original

Licencia

Derechos de autor 2024 Geraldo Bezerra Silva Junior, Ana Amélia Reis Jereissati, José Reginaldo Pinto, Rodrigo Tavares Dantas, Janaína de Almeida Mota Ramalho, Gdayllon Cavalcante Meneses

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

 

 

Cómo citar

1.
Silva Junior GB, Jereissati AAR, Pinto JR, Dantas RT, Ramalho J de AM, Meneses GC. Chronic kidney disease as an aggravating factor in dengue virus infection. Medicina (Ribeirão Preto) [Internet]. 2024 Dec. 27 [cited 2025 Mar. 12];57(3):e-213689. Available from: https://periodicos.usp.br/rmrp/article/view/213689

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