Doença renal crônica como fator agravante da infecção pelo vírus da dengue: um estudo transversal
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2024.213689Palavras-chave:
Dengue, Dengue grave, Doença renal crônica, Mortalidade, Evolução fatalResumo
Introdução: A infecção pelo vírus da dengue é um problema de saúde pública em todo o mundo, podendo se manifestar desde um quadro febril leve até uma doença grave, com envolvimento de múltiplos órgãos, incluindo doença renal. O objetivo deste estudo foi analisar os casos de dengue avaliando como a doença renal crônica (DRC) agrava suas manifestações clínicas. Métodos: Estudo transversal realizado no banco de dados da Secretaria de Saúde do Estado do Ceará, Nordeste do Brasil, no período de janeiro de 2015 a dezembro de 2017. Foi feita comparação entre pacientes com e sem DRC. Resultados: Foram incluídos 161.880 pacientes. Os pacientes com DRC tinham idade mais avançada (41±22 vs. 35±21 anos, p<0,001), predominantemente do sexo feminino (62 vs. 57%, p=0,004) e apresentavam maior frequência de alguns sinais e sintomas. No entanto, o único sinal de alerta mais prevalente entre os pacientes com DRC foi a letargia (0,5% vs. 0,004%, p=004). As comorbidades mais comuns foram hipertensão e diabetes, que também são as causas mais comuns de DRC (51 vs. 3,3% / 42 vs. 1,3%, p<0,001). A necessidade de internação foi significativamente mais frequente no grupo com DRC (12,3% vs. 2,2%, p<0,001), sendo a mortalidade maior nos pacientes com DRC (2,2% vs. 0,1%, p<0,001). Os fatores de risco independentes para óbito foram: idade, vômitos, leucopenia, diabetes, DRC e hipertensão. Conclusões: A DRC agrava a severidade da dengue e as pessoas com essa comorbidade devem ser cuidadosamente monitoradas, principalmente em períodos epidêmicos.
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Copyright (c) 2024 Geraldo Bezerra Silva Junior, Ana Amélia Reis Jereissati, José Reginaldo Pinto, Rodrigo Tavares Dantas, Janaína de Almeida Mota Ramalho, Gdayllon Cavalcante Meneses
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico
Números do Financiamento 310974/2020-8
