Age as a prognostic factor in early breast cancer
DOI:
https://doi.org/10.1590/S0034-89102009005000009Keywords:
Women, Breast Neoplasms, Age of Onset, Age Effect, Early Diagnosis, Prognosis, Retrospective StudiesAbstract
OBJECTIVE: To analyze age as a prognostic factor in early breast cancer. METHODS: Retrospective study analyzing the clinical profile and disease-free survival in a group of 280 subjects aged 25 to 81 years with stage I and II breast cancer followed-up in Porto Alegre, southern Brazil, from 1995 to 2000. Clinical, pathological, treatment and outcome data were obtained from medical records. Subjects were divided into two groups according to age at diagnosis (<40 years and >;40 years). The two groups were compared for clinical stage, histology, hormone receptor expression, therapy and radiotherapy using the chi-square and/or Fisher's exact test and for analysis of survival the Kaplan-Meier method with a long-rank test. RESULTS: Of 280 women studied, 54 (19.3%) were younger than 40 years. Both groups were similar regarding clinical stage, histology, and hormone receptor expression. The proportion of subjects with disease-free survival in the 56-month follow-up was significantly higher in those over 40 years (84% versus 70%). Proportionally, younger subjects received more adjuvant therapy (88.8% vs. 77.8%). Those women over 40 years were significantly more likely to remain disease-free (84%), and this difference was more remarkable when they were compared to those over 40 years at stage I breast cancer. CONCLUSIONS: The study findings confirm that women younger than 40 years with early breast cancer have a poorer prognosis. However, this prognosis does not seem to be related to increased number of hormone receptor-negative cases. Younger patients who remained disease-free received more adjuvant therapy, suggesting a positive effect of chemotherapy and endocrine therapy.Downloads
Published
2009-04-01
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Original Articles
How to Cite
Garicochea, B., Morelle, A., Andrighetti, A. E., Cancella, A., Bós, Ângelo, & Werutsky, G. (2009). Age as a prognostic factor in early breast cancer . Revista De Saúde Pública, 43(2), 311-317. https://doi.org/10.1590/S0034-89102009005000009