Experimental assay of the possible use of gentian violet in the prevention of post-transfusion malaria
DOI:
https://doi.org/10.1590/S0034-89101987000600005Keywords:
Malaria^i2^sprevention and cont, Gentian violet^i2^spharmacodynam, Plasmodium berghei^i2^sdrug effe, Mice^i2^sparasitol, Blood transfusion^i2^sadverse effeAbstract
Considering that gentian violet is effective in the prevention of transfusion-acquired Chagas' disease and possibly toxoplasmosis, it is decided to carry out an experimental assay on the acitvity of this dye in the prevention of post-transfusion malaria. Mice infected with Plasmodium berghei were studied with regard to parasitemia, mortality and histopathologic changes. Gentian violet added to blood in 1/1.000 and 1/4.000 concentrations turned out to be effective in abolishing infectivity after storage for 24 hours at 4°C. Thus is opened up a new prospect in the prophylaxis of post-transfusion malaria.Downloads
Published
1987-12-01
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Section
Original Articles
How to Cite
Amato Neto, V., Sant'Ana, E. J. de, Pinto, P. L. S., Moreira, A. A. B., Duarte, M. I. S., & Campo, R. (1987). Experimental assay of the possible use of gentian violet in the prevention of post-transfusion malaria . Revista De Saúde Pública, 21(6), 497-500. https://doi.org/10.1590/S0034-89101987000600005